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ELISAs for free light chains of human immunoglobulins using monoclonal antibodies: comparison of their specificity with available polyclonal antibodies. J Immunol Methods ; : 9— Analytical performance of serum free light-chain assay during monitoring of patients with monoclonal light-chain diseases.

Clin Chim Acta ; : 30— Risk of antigen excess in serum free light chain measurements. Clin Chem ; 53 : — Urinary free light chain analysis by the Freelite immunoassay: a preliminary study in multiple myeloma.

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Clin Biochem ; 35 : — Prognostic value of the serum-free light chain ratio in patients with newly diagnosed myeloma and proposed incorporation into the International Staging System. Leukemia ; 22 : — Serum-free light chains for monitoring multiple myeloma. Br J Haematol ; : — Clinical usefulness of free light chain concentration as a tumor marker in multiple myeloma. Ann Hematol ; 84 : — Appraisal of immunoglobulin free light chain as a marker of response. Blood ; : — Serum free light-chain measurements for identifying and monitoring patients with nonsecretory multiple myeloma.

Blood ; 97 : — Correlation of serum immunoglobulin free light chain quantification with urinary Bence Jones protein in light chain myeloma.

International myeloma working group guidelines | Wikilite

Immunoglobulin free light chain ratio is an independent risk factor for progression of smoldering asymptomatic multiple myeloma. Serum free light chain ratio is an independent risk factor for progression in monoclonal gammopathy of undetermined significance. Quantitative analysis of serum free light chains. A new marker for the diagnostic evaluation of primary systemic amyloidosis. Am J Clin Pathol ; : — Outcome in systemic AL amyloidosis in relation to changes in concentration of circulating free immunoglobulin light chains following chemotherapy.

Br J Haematol ; : 78— Elimination of the need for urine studies in the screening algorithm for monoclonal gammopathies by using serum immunofixation and free light chain assays. Mayo Clin Proc ; 81 : — Can serum free light chains replace urine electrophoresis in the detection of monoclonal gammopathies? Ann Clin Biochem ; 44 : — Serum free light chain analysis and urine immunofixation electrophoresis in patients with multiple myeloma. Clin Cancer Res ; 11 : — Serum free light chains: an alternative to the urine Bence Jones proteins screening test for monoclonal gammopathies.

Clin Chem ; 52 : — Assessment of serum free light chain assays for plasma cell disorder screening in a veterans affairs population. Ann Clin Lab Sci ; 36 : — Detection of monoclonal proteins in sera by capillary zone electrophoresis and free light chain measurements. High incidence of IgH translocations in monoclonal gammopathies with abnormal free light chain levels. Absolute values of immunoglobulin free light chains are prognostic in patients with primary systemic amyloidosis undergoing peripheral blood stem cell transplantation.

High serum-free light chain levels and their rapid reduction in response to therapy define an aggressive multiple myeloma subtype with poor prognosis. Clinical course and prognosis of smoldering asymptomatic multiple myeloma. New Engl J Med ; : — Immunoglobulin free light chains and solitary plasmacytoma of bone. Prognostic value of serum free light chain ratio at diagnosis in multiple myeloma. International staging system for multiple myeloma.

How can multiple myeloma and MGUS present?

J Clin Oncol ; 23 : — Circulating amyloidogenic free light chains and serum N-terminal natriuretic peptide type B decrease simultaneously in association with improvement of survival in AL. Serum free light-chain responses after high-dose intravenous melphalan and autologous stem cell transplantation for AL primary amyloidosis.

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Bone Marrow Transplant ; 36 : — Definition of organ involvement and treatment response in immunoglobulin light chain amyloidosis AL : a consensus opinion from the 10th International Symposium on Amyloid and Amyloidosis, Tours, France, 18—22 April Am J Hematol ; 79 : — International uniform response criteria for multiple myeloma. Leukemia ; 20 : — Criteria for evaluating disease response and progression in patients with multiple myeloma treated by high-dose therapy and haemopoietic stem cell transplantation.

European Group for Blood and Marrow Transplant. The serum-free light chain assay cannot replace h urine protein estimation in patients with plasma cell dyscrasias. Free light chain assays for early detection of resistance to bortezomib-based regimens. Haematologica ; 92 : Doxorubicin and dexamethasone followed by thalidomide and dexamethasone is an effective well tolerated initial therapy for multiple myeloma.

Extramedullary relapse of multiple myeloma associated with a shift in secretion from intact immunoglobulin to light chains. Haematologica ; 92 : — Download references. Correspondence to A Dispenzieri. Reprints and Permissions. Dispenzieri, A. International Myeloma Working Group guidelines for serum-free light chain analysis in multiple myeloma and related disorders. Leukemia 23, — doi Download citation. Gene Therapy Blood Cancer Journal Nature Reviews Nephrology Annals of Hematology Advanced search.

Skip to main content. Access through your institution. Buy or subscribe. Download PDF. Introduction The monoclonal plasmaproliferative disorders encompass a broad spectrum of diseases ranging from the often benign monoclonal gammopathy of undetermined significance MGUS to the potentially curable solitary plasmacytoma to the life-threatening conditions of multiple myeloma MM and light chain amyloidosis AL. Figure 1. Full size image. Immunoglobulin-free light chain production and measurement Serum concentrations of FLC are dependent on the balance between production by plasma cells and renal clearance.

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25.3. International Myeloma Working Group guidelines

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